Publication

Abstract : Spirocarbocyclic‐oxindole is priviledged scaffold in heterocyclic chemistry, which paved the attention of synthetic chemist due to generation of a new stereocenter. Numerous methodologies have been developed for spirooxindoles but very few methods are available for carbocyclic oxindoles. Most of the reported cycloaddition reactions are five membered rings instead of six membered rings, tethered with oxindole scaffold. Lewis acid catalysed Diels Alder reaction is a comparatively better approach to functionalize this unique scaffold. An efficient diastereoselective synthesis of spirocarbocyclic‐oxindoles with six membered cabocyclic backbone was achieved via ZrCl4 catalyzed [4+2] cycloaddition of α‐ylideneoxindoles with dienes in good to excellent yields within a short span of time.