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Unveiling thiol biomarkers: Glutathione and cysteamine

Publication Type : Journal Article

Publisher : Clinica Chimica Acta

Source : Clinica Chimica Acta (2024): 119915

Url : https://doi.org/10.1016/j.cca.2024.119915

Campus : Amritapuri

School : School of Physical Sciences

Department : Chemistry

Year : 2024

Abstract : The physiological and clinical importance of Glutathione and Cysteamine is emphasized by their participation in a range of conditions, such as diabetes, cancer, renal failure, Parkinsons disease, and hypothyroidism. This necessitates the requirement for accessible, expedited, and cost-efficient testing that can facilitate clinical diagnosis and treatment options. This article examines numerous techniques used to detect both glutathione and cysteamine. The discussed methods include electroanalytical techniques such as voltammetry and amperometry, which are examined for their sensitivity and ability to provide real-time analysis. Furthermore, this study investigates the accuracy of gas chromatography-mass spectrometry (GCMS) and high-performance liquid chromatography (HPLC) in measuring the concentrations of glutathione and cysteamine. Additionally, the potential of new nanotechnology-based methods, such as plasmonic nanoparticles and quantum dots, to improve the sensitivity of detecting glutathione and cysteamine is emphasized.

Cite this Research Publication : Gopika, M. G., Surya Gopidas, Gokul S. Jayan, P. S. Arathy, and Beena Saraswathyamma. "Unveiling thiol biomarkers: Glutathione and cysteamine." Clinica Chimica Acta (2024): 119915

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