Publication Type : Journal Article
Publisher : American Chemical Society
Source : Organic Letters, 2013
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2013
Abstract : A highly concise stereoselective synthesis of a newly identified alkaloid with a pyrroloindoloquinazoline skeleton has been achieved. To this end, a chiral auxiliary mediated asymmetric acetate aldol reaction on tryptanthrin was explored and the resulting adduct was converted to the product by a novel one-pot reductive cyclization/transamidation using NiCl2·6H2O/NaBH4 in methanol.
Cite this Research Publication : Digvijay Gahtory, Mangilal Chouhan, Ratnesh Sharma, and Vipin A. Nair "Total Synthesis of a Pyrroloindoloquinazoline Alkaloid", Organic Letters 2013, 15, 3942-3945