Publication Type : Book Chapter
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Springer Berlin Heidelberg,
Source : Ion Channels and Their Inhibitors, Springer Berlin Heidelberg, Berlin, Heidelberg, p.289–308 (2011)
Url : https://doi.org/10.1007/978-3-642-19922-6_10
ISBN : 9783642199226
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2011
Abstract : Voltage-gated N-type Ca2+ channels (NCCs) play dominant roles in neuropathic pain and cerebral ischemia. Ion channel therapeutics for many pathophysiological conditions exists, which include: affective disorders, allergic disorders, autoimmune diseases, epilepsy, hypertension, insomnia, pain, anesthesia, anxiety, and stroke. Experimentally, it was well established that NCC inhibitory activity is essential for the treatment of chronic neuropathic pain and stroke. A major obstacle with these membrane proteins is that the atomic resolution experimental structures are not available to understand the mode of small molecule binding at its active sites. This article mainly focuses on Ca2+ channel blockers (CCBs), especially for NCCs, wherein lie some of the opportunities and advantages associated with these channels as drug target.
Cite this Research Publication : Dr. Gopi Mohan C., Pandey, A., and Mungalpara, J., “Therapeutic Potential of N-Type Voltage-Gated Ca2+ Channel”, in Ion Channels and Their Inhibitors, S. Prakash Gupta, Ed. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011, pp. 289–308.