Publication

Abstract : Considering the diverse applications and importance of DNA topoisomerases II (TOP II) inhibitorsin biological systems, it is vital to understand the fundamental organic chemistry of these inhibitoryagents through various synthetic strategies and it is crucial for further developments of thesame. Many of the reported TOP II inhibitors are associated with extreme structural complexities andrequire multi-step synthetic routes providing difficulties towards their preparation and modifications.The present work describes the synthetic protocols for a diverse array of candidates relating to bothTOP II poisons and catalytic inhibitors which may be useful for further synthetic developments.