Publication Type : Journal Article
Publisher : Medicinal Chemistry Research.
Source : Medicinal Chemistry Research. 2013 Oct 1;22(10):4980-91
Url : https://doi.org/10.1007/s00044-013-0510-y
Campus : Kochi
School : School of Pharmacy
Center : Research & Projects
Department : Pharmacognosy
Verified : Yes
Year : 2013
Abstract : The synthesis of a series of substituted 2-(piperazin-1-yl)benzothiazole/benzoxazole coupled with 1,3,4-oxadiazole-2-thiol pharmacophore (8a–t) is described using a three carbon spacer (Jones and Helm, Drugs 69:1903–1910, 2009). The structures of the compounds were confirmed by NMR and mass spectral data. All the synthesized compounds have been evaluated for their cytotoxicity towards five human cancer cell lines of different origins, viz. MCF-7 (Breast), HeLa (Cervical), HepG2 (Liver), A431 (Skin) and A549 (Lung), and IC50 values were determined. Among the compounds tested, 8j and 8t displayed maximum cytotoxic activity. A431 was the most sensitive cell line against the compounds studied, followed by MCF7, A549,