Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Carbohydrate Polymers
Source : Carbohydrate Polymers, Volume 78, Number 4, p.672 - 677 (2009)
Url : http://www.sciencedirect.com/science/article/pii/S0144861709003129(link is external)
Keywords : Antibacterial, Biomaterials, Carboxymethyl derivatives, Chitosan nanoparticles, cytotoxicity
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2009
Abstract : Chitosan (CS) is a naturally occurring biopolymer. It has important biological properties such as biocompatibility, antifungal and antibacterial activity, wound healing ability, anticancerous property, anticholesteremic properties, and immunoenhancing effect. Recently, CS nanoparticles have been used for biomedical applications. However, due to the limited solubility of CS in water its water-soluble derivatives are preferred for the above said applications. In this work, the nanoparticles of CS and its water-soluble derivatives such as O-carboxymethyl chitosan (O-CMC) and N,O-carboxymethyl chitosan (N,O-CMC) was synthesized and characterized. In addition, cytotoxicity and antibacterial activity of the prepared nanoparticles was also evaluated for biomedical applications.
Cite this Research Publication : A. Anitha, Rani, V. V. Divya, Krishna, R., Sreeja, V., Selvamurugan, N., Shantikumar V Nair, Tamura, H., and Dr. Jayakumar Rangasamy, “Synthesis, Characterization, Cytotoxicity and Antibacterial Studies of Chitosan, O-carboxymethyl and N,O-carboxymethyl Chitosan Nanoparticles”, Carbohydrate Polymers, vol. 78, pp. 672 - 677, 2009.