Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Carbohydrate Polymers
Source : Carbohydrate Polymers, Volume 87, Number 1, p.943 - 949 (2012)
Url : http://www.sciencedirect.com/science/article/pii/S0144861711007284
Keywords : Chitin nanogels, Drug delivery, swelling, tissue engineering
Campus : Kochi
School : Center for Nanosciences, School of Pharmacy
Center : Nanosciences
Department : Nanosciences and Molecular Medicine, Pharmacology
Year : 2012
Abstract : Abstract In this work we developed biodegradable chitin nanogels (CNGs) of size 65nm by controlled regeneration method and characterized. The CNGs showed higher swelling and degradation in acidic pH. The in vitro cytocompatibility was analyzed on an array of cell lines and cell uptake studies were done by conjugating CNGs with the rhodamine-123 dye (rhodamine-123–CNGs), which showed retention of nanogels inside the cells. Our preliminary studies reveal that these nanogels could be useful for the delivery of drugs, growth factors for drug delivery and tissue engineering.
Cite this Research Publication : S. N. Rejinold, Nair, A., Dr. Sabitha M., Chennazhi, K. P., Tamura, H., Nair, S. V., and Dr. Jayakumar Rangasamy, “Synthesis, Characterization and in vitro Cytocompatibility Studies of Chitin Nanogels for Biomedical Applications”, Carbohydrate Polymers, vol. 87, pp. 943 - 949, 2012