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Publication Type : Journal Article
Publisher : Ind J Pharm Educ Res
Source : Ind J Pharm Educ Res, Volume 47, Number 4, p.31–38 (2013)
Url : http://www.ijper.org/sites/default/files/ijper_47_4_5.pdf
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutical Chemistry & Analysis
Verified : Yes
Year : 2013
Abstract : A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationally designed leading to a focused library of ligands 4a-j with ring-A substitution. Subsequent to drug-likeness and druggability assessments, the library members were synthesized in optimal yields and their structures were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. Screening for anti-inflammatory activity revealed that most of the compounds were quite effective in containing inflammation with compound 4b being the most promising derivative
Cite this Research Publication : R. Balasubramanian, Iqbal, H., Vijayagopal, R., and Chandrika, B., “Synthesis and preliminary evaluation of a focused chalcone library for anti-inflammatory activity”, Ind J Pharm Educ Res, vol. 47, pp. 31–38, 2013.