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Synthesis and Discovery of (I-3,II-3)-Biacacetin as a Novel Non-zinc Binding Inhibitor of MMP-2 and MMP-9

Publication Type : Journal Article

Thematic Areas : Biotech

Publisher : Bioorganic Medicinal Chemistry

Source : Bioorganic & Medicinal Chemistry, Volume 23, Number 13, p.3781 - 3787 (2015)

Url : http://www.sciencedirect.com/science/article/pii/S0968089615002916

Keywords : MMP-2 and MMP-9

Campus : Amritapuri, Coimbatore

School : School of Biotechnology, School of Physical Sciences

Center : Biotechnology, Cell Biology, Phytochemistry Labs

Department : biotechnology, Department of Sciences

Year : 2015

Abstract : Abstract Eleven biflavones (7a–b and 9a–i) were synthesised by a simple and efficient protocol and screened for MMP-2 and MMP-9 inhibitory activities. Amongst them, a natural product-like analog, (I-3,II-3)-biacacetin (9h) was found to be the most potent inhibitor. Molecular docking studies suggest that unlike most of the known inhibitors, 9h inhibits MMP-2 and MMP-9 through non-zinc binding interactions.

Cite this Research Publication : Pandurangan Nanjan, Dr. Jyotsna Nambiar, Dr. Bipin G. Nair, and Dr. Asoke Banerji, “Synthesis and Discovery of (I-3,II-3)-Biacacetin as a Novel Non-zinc Binding Inhibitor of MMP-2 and MMP-9”, Bioorganic & Medicinal Chemistry, vol. 23, pp. 3781 - 3787, 2015

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