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Synthesis and Characterization of pH-Sensitive Thiol-Containing Chitosan Beads for Controlled Drug Delivery Applications

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : Drug Delivery

Source : Drug Delivery, Taylor & Francis, Volume 14, Number 1, p.9-17 (2007)

Url : https://doi.org/10.1080/10717540600739872

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2007

Abstract : The aim of this study was to develop chitosan-based materials in drug delivery systems possessing covalent attachment of thiol moieties. Thiol-containing chitosan (TCS), found to be soluble in water, was synthesized by graft copolymerization technique. The TCS beads were prepared by using tripolyphoshate, at pH 4.0. The morphology of TCS beads was examined by scanning electron microscopy. The in vitro drug release behavior was studied in phosphate buffer solution at various pH, using indomethacin as a model drug at two different concentrations (0.3 and 0.6% w/w). The release amounts of indomethacin from TCS beads were higher increasing pHs in the dissolution medium. The release rate of indomethacin at pH 7.4 was higher than the release rate at pH 1.4 due to ionization of thiol groups and high solubility of indomethacin in an alkaline medium. These results indicated that the TCS beads may become a delivery system for the controlled release of different drugs wherever pH sensitive mechanics might be useful. This is especially applicable in cases when it is important to minimize drug release in acidic sites, such as in the stomach.

Cite this Research Publication : Dr. Jayakumar Rangasamy, Reis, R. L., and Mano, J. F., “Synthesis and Characterization of pH-Sensitive Thiol-Containing Chitosan Beads for Controlled Drug Delivery Applications”, Drug Delivery, vol. 14, pp. 9-17, 2007.

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