Publication

Abstract : Fibrous scaffolds are commonly used as scaffolds in tissue engineering as they have remarkably high surface-area-to-volume ratio. Surface modification of fibrous constructs by employing innovative post-processing techniques such as chemical modifications, using coating gradients or active cues, avenues for tuning cellular respones. Most of the commercial polymers/unmodified polymeric scaffolds contribute little to generate biological activity. The below described methods offer plethora of chances by altering the complexity of fibers for efficient scale-up that would be relevant for industrial applications. It is also to be taken into consideration that while modifying the surface of these fibers, the mechanical properties of the materials are to be retained as such. In this chapter, we have discussed about the various modification chemistry and techniques to improve biological activity of the fibrous scaffolds.