Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Medicinal Chemistry Research
Source : Medicinal Chemistry Research, Volume 23, Number 2, p.735–746 (2014)
Url : https://doi.org/10.1007/s00044-013-0677-2
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2014
Abstract : $alpha$2A-, $alpha$2B-, and $alpha$2C-adrenoceptors belong to the rhodopsin-like G-protein coupled receptors family. They are integral membrane proteins typified by a bundle of seven transmembrane helices. 50nbsp;{%} of the currently available drugs in the market target G-protein coupled receptors. Crystal structure of $alpha$2A-, $alpha$2B-, and $alpha$2C-adrenoceptors are not yet solved. We performed homology modeling of the human $alpha$2A-, $alpha$2B-, and $alpha$2C-adrenoceptor subtypes based on the crystal structure of the $beta$2-adrenergic receptor. Molecular docking studies of five different antagonists toward these receptors revealed receptor subtype selectivity, and which in turn potentially guide in the rational design of subtype selective antagonists.
Cite this Research Publication : V. Kumar, Bansal, G., Patel, J., and Dr. Gopi Mohan C., “Structure–Function Prediction of $\alpha$2A-, $\alpha$2B-, and $\alpha$2C-Adrenoceptors using Homology Model Assisted Antagonist Binding Study”, Medicinal Chemistry Research, vol. 23, pp. 735–746, 2014.