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Publication Type : Journal Article
Publisher : Chemical Physics
Source : Chemical Physics, 393, 58, 2012
Url : https://www.sciencedirect.com/science/article/abs/pii/S0301010411005180
Campus : Coimbatore
School : School of Artificial Intelligence
Center : Center for Computational Engineering and Networking
Year : 2012
Abstract : In the spirit of Gillespie’s stochastic approach we have formulated a theory to explore the advancement of the interfacial enzyme kinetics at the single enzyme level which is ultimately utilized to obtain the ensemble average macroscopic feature, lag-burst kinetics. We have provided a theory of the transition from the lag phase to the burst phase kinetics by considering the gradual development of electrostatic interaction among the positively charged enzyme and negatively charged product molecules deposited on the phospholipid surface. It is shown that the different diffusion time scales of the enzyme over the fluid and product regions are responsible for the memory effect in the correlation of successive turnover events of the hopping mode in the single trajectory analysis which again is reflected on the non-Gaussian distribution of turnover times on the macroscopic kinetics in the lag phase unlike the burst phase kinetics.
Cite this Research Publication : Stochastic theory of interfacial enzyme kinetics: A kinetic Monte Carlo study, B. Das, and G. Gangopadhyay, Chemical Physics, 393, 58, 2012