Publication Type : Journal Article
Publisher : Wiley
Source : Asian Journal of Organic Chemistry, 2016
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2016
Abstract : (S)‐4‐Isopropyl‐1‐[(R)‐1‐phenylethyl]imidazolidin‐2‐one was evaluated as a chiral auxiliary for asymmetric acetate and propionate Mannich‐type reactions, by generation of the titanium enolates, affording excellent yields and stereoselectivities. The application of the auxiliary was exemplified in the stereoselective synthesis of the β‐lactam antihyperlipidemic drug ezetimibe.
Cite this Research Publication : Sandeep Goyal, Anamika Thakur, Ratnesh Sharma, Mukesh Gangar, Bhautikkumar Patel and Vipin A. Nair, "Stereoselective Alkylation of Imines and its Application towards the Synthesis of β‐Lactams", Asian Journal of Organic Chemistry 2016, 5, 1359-1367