Publication Type : Journal Article
Source : NAJMC
Url : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560138/
Campus : Faridabad
School : School of Medicine
Year : 2013
Abstract :
Background:
Pre-eclampsia is one of the leading causes of high rates of maternal and perinatal mortality and morbidity. Pathophysiology of pre-eclampsia is still obscure. Currently, there are no screening tests for pre-eclampsia that are reliable, valid, and economical. Parameters of oxidative stress could be early markers of endothelial dysfunction that predates clinical pre-eclampsia.
Aim:
This study was to study ceruloplasmin in nulliparous women as marker of oxidative stress and lipid profile to evaluate their value in prediction of pre-eclampsia.
Materials and Methods:
Prospective observational study. 306 nulliparous women had their serum lipid profile and ceruloplasmin levels measured at 14-16 weeks period of gestation as sample 1 and at 18-20 weeks as sample 2. All cases were followed up till the end of pregnancy for development of pre-eclampsia.
Results:
There was no statistically significant difference between the normals and pre-eclampsia cases at 14-16 week for all the oxidative stress parameters (P > 0.05), but at 18-20 week, there was statistically significant difference between the normals and pre-eclampsia cases in cholesterol and ceruloplasmin parameters (P < 0.05).
Conclusion:
Cholesterol and ceruloplasmin levels in second trimester (18-20 weeks) can predict the development of pre-eclampsia.
Cite this Research Publication : Madhusudan Dey, Devendra Arora, Nagarja Narayan, and Reema Kumar, Serum Cholesterol and Ceruloplasmin Levels in Second Trimester can Predict Development of Preeclampsia, NAJMC, 2013.