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SARS-CoV-2—host cell interactions and pathways: understanding its physiology, pathology, and targeted drug therapy

Publication Type : Book Chapter

Publisher : Pandemic Outbreaks in the 21st Century

Source : Pandemic Outbreaks in the 21st Century, 2021

Url : https://www.researchgate.net/publication/354332671_SARS-CoV-2-host_cell_interactions_and_pathways_understanding_its_physiology_pathology_and_targeted_drug_therapy

Campus : Bengaluru

School : School of Engineering

Center : Amrita Innovation & Research

Department : Chemistry

Verified : Yes

Year : 2021

Abstract : COVID-19 is an emerging pandemic that has affected millions of individuals for the past few months by causing severe damage to lives, health, and economy globally. Even with concentrated research efforts globally, a properly approved vaccine or antiviral therapy is yet unavailable. With the advent of innovative high-throughput technologies including genomics, transcriptomics, and proteomics, novel insights into the SARS-CoV-2 replication cycle and its interaction of the host cell and systems have been obtained. This information can shed light on the intimate relationship between the virus and its host, serving as the basis to develop optimal prophylactic and therapeutic treatment options. In this chapter we provide a comprehensive outline of the current status of the SARS-CoV-2 research, encompassing every step of the viral replication cycle with a specific focus on virus–host cell interaction. We also review specific chemical inhibitors targeting cellular factors and processes of relevance for the SARS-CoV-2 replication cycle and their possible exploitation for the development of next-generation antivirals.

Cite this Research Publication : Gonsalves, Rhea & Pacharla, Himavani & Manohar, Sai & Belliraj, Siva Kumar & Tripathi, Ekta & Karyala, Prashanthi & Pakala, Suresh. (2021). SARS-CoV-2—host cell interactions and pathways: understanding its physiology, pathology, and targeted drug therapy. 10.1016/B978-0-323-85662-1.00006-9.

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