Publication Type : Journal Article
Publisher : Organic Letters
Source : Organic Letters, Volume 18, Number 3, p.356-359 (2016)
Url : http://dx.doi.org/10.1021/acs.orglett.5b03185
Campus : Amritapuri
School : School of Arts and Sciences
Department : Chemistry
Year : 2016
Abstract : A ruthenium catalyzed intramolecular C–S coupling reaction of N-arylthioureas for the synthesis of 2-aminobenzothiazoles has been developed. Kinetic, isotope labeling, and computational studies reveal the involvement of an electrophilic ruthenation pathway instead of a direct C–H activation. Stereoelectronic effect of meta-substituents on the N-arylthiourea dictates the final regioselective outcome of the reaction.
Cite this Research Publication : Shivani Sharma, Ramdas S. Pathare, Antim K. Maurya, Dr. Gopal K., Tapta Kanchan Roy, Devesh M. Sawant, and Ram T. Pardasani, “Ruthenium Catalyzed Intramolecular C–S Coupling Reactions: Synthetic Scope and Mechanistic Insight”, Organic Letters, vol. 18, pp. 356-359, 2016