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Publication Type : Journal Article
Publisher : Asian J Transfus Sci
Source : Asian J Transfus Sci 2020; 14:70-314
Url : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7607993/
Campus : Faridabad
Year : 2020
Abstract : There are several reports in medical literature about Red Cell Exchange (RCE) being routinely performed pre-operatively in sickle cell disease patients to provide immediate decrease in HbS concentration and prevent post-operative complications. We would like to present one such case of SCD who also had multiple allo-antibodies and had to undergo hemi-arthroplasty for avascular necrosis of head femur. Grouping and antibody screening was performed using column agglutination technique. 3-cell and 11- cell panel were used for antibody screening and identification, respectively. Automated RBC exchange was performed on apheresis machine Com. Tec using the standard PL1 kit (Fresenius Kabi, Germany). Multiple (anti-c, E) allo-antibodies were identified and successful pre-operative RCE was done with corresponding antigen-negative AHG compatible RBC units. Single RCE procedure reduced HbS concentration from 65% to 25%. The patient underwent uneventful hemi-arthroplasty and was discharged on post-operative day-7. Patient is on regular follow-up and continues to do well two months after the day of surgery. This is possibly the first case report from India, which illustrates successful automated RCE in a SCD patient with alloimmunization.
Cite this Research Publication : Aggarwal G, Tiwari AK, Dhiman P, Arora D, Pabbi SM, Setya D. Red blood cell exchange in sickle cell disease patient with multiple alloantibodies. Asian J Transfus Sci 2020; 14:70-314