Programs
- B. Sc. Clinical Nutrition, Dietetics, and Food Science - Undergraduate
- Post Doctoral Fellowship in EEG & Clinical Epileptology - Fellowship
Publication Type : Journal Article
Publisher : Elsevier
Source : Tetrahedron Letters, 2013
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2013
Abstract : A highly efficient organocatalytic approach has been developed for the diastereoselective epoxidation of (E)-3-ylidene-indolin-2-one derivatives using readily available natural product quinine and urea-hydrogen peroxide (UHP) in DCM at 10° C to afford trans spiro- epoxyoxindoles which were further utilized to obtain β-hydroxy-α-amino esters by water mediated regioselective ring opening from the less hindered end with aniline derivatives, under sonication.
Cite this Research Publication : Mangilal Chouhan, Anang Pal, Ratnesh Sharma and Vipin A. Nair, "Quinine as an organocatalytic dual activator for the diastereoselective synthesis of spiroepoxyoxindoles", Tetrahedron Letters, 2013, 54, 7119-7123