Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : ACS Biomaterials Science & Engineering,
Source : ACS Biomaterials Science & Engineering, Volume 1, Number 12, p.1194-1199 (2015)
Url : https://doi.org/10.1021/acsbiomaterials.5b00361
Campus : Coimbatore, Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2015
Abstract : The efficacy of protein-vorinostat nanomedicine (NV) is demonstrated in leukemic stem cells (LSC) isolated from refractory acute myeloid leukemia (AML) patient samples, where it successfully ablated both CD34+ CD38– CD123+ LSC and non-LSC “leukemic blast” compartments, without inducing myelosuppression or hemotoxicity. Besides, NV also exerted excellent synergistic lethality against leukemic bone marrow cells (BMC) at lower concentrations (0.1 μM) in combination with DNA methyltransferase (DNMT) inhibitor, decitabine. Considering the extermination of resilient LSC and synergism with decitabine, NV shows promise for clinical translation in the setting of a more tolerable and effective epigenetic targeted therapy for leukemia
Cite this Research Publication : P. Chandran, Pavithran, K., Sidharthan, N., Sasidharan, A., Shantikumar V Nair, and Dr. Manzoor K., “Protein Nanomedicine Exerts Cytotoxicity toward CD34+ CD38– CD123+ Leukemic Stem Cells”, ACS Biomaterials Science & Engineering, vol. 1, pp. 1194-1199, 2015.