Back close

Prioritizing single-nucleotide polymorphisms and variants associated with clinical mastitis.

Publication Type : Journal Article

Publisher : Adv Appl Bioinform Chem. 2017 Jun 12;10:57-64.

Source : Adv Appl Bioinform Chem. 2017 Jun 12;10:57-64.

Url : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473491/

Keywords : clinical mastitis, single-nucleotide polymorphisms, variants, associations, diseases, linkage disequilibrium, GWAS

Campus : Amritapuri

School : School of Biotechnology

Department : biotechnology

Year : 2017

Abstract : Next-generation sequencing technology has provided resources to easily explore and identify candidate single-nucleotide polymorphisms (SNPs) and variants. However, there remains a challenge in identifying and inferring the causal SNPs from sequence data. A problem with different methods that predict the effect of mutations is that they produce false positives. In this hypothesis, we provide an overview of methods known for identifying causal variants and discuss the challenges, fallacies, and prospects in discerning candidate SNPs. We then propose a three-point classification strategy, which could be an additional annotation method in identifying causalities.

Cite this Research Publication : Suravajhala P, Benso A. Prioritizing single-nucleotide polymorphisms and variants associated with clinical mastitis. Adv Appl Bioinform Chem. 2017 Jun 12;10:57-64

Admissions Apply Now