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Predictive Ability of Amplitude Integrated Electroencephalography for Adverse Outcomes in Neonates with Sepsis-Associated Encephalopathy: A Cohort Study

Publication Type : Journal Article

Publisher : Springer Science and Business Media LLC

Source : Indian Journal of Pediatrics

Url : https://doi.org/10.1007/s12098-024-05098-x

Campus : Faridabad

School : School of Medicine

Year : 2024

Abstract : The authors examined the prevalence of abnormal amplitude integrated electroencephalography (aEEG) patterns in neonates diagnosed with sepsis-associated encephalopathy (SAE). They recorded 36626 min of aEEG in 75 study neonates. Encephalopathy was defined by the Brighton Collaboration Neonatal Encephalopathy criteria. Neonates with primary outcome [either non-survivors or survivors with abnormal neurological examination at discharge using Amiel-Tison assessment tool, n = 58, (77%)] were compared with 17 survivors having normal neurological examination at discharge. Severely abnormal aEEG patterns (isoelectric voltage, continuous low voltage, burst suppression) collectively represented 31% of total 36626 min aEEG tracings. Neonates experiencing primary outcome had significantly higher Burdjalov scores than survivors with normal neurological exam (p value 0.01). After adjusting for gestational age, birth weight, and invasive ventilation, severely abnormal aEEG (aOR 5.8, 95% CI 1.7–19.5, p value 0.005) and Burdjalov score (aOR 0.77, 95% CI 0.63–0.95, p value 0.01) were independently associated with death or abnormal neurological examination at discharge.

Cite this Research Publication : Priyansh Jain, Shiv Sajan Saini, Jitendra Kumar Sahu, Priyanka Madaan, Venkataseshan Sundaram, Sourabh Dutta, Predictive Ability of Amplitude Integrated Electroencephalography for Adverse Outcomes in Neonates with Sepsis-Associated Encephalopathy: A Cohort Study, Indian Journal of Pediatrics, Springer Science and Business Media LLC, 2024, https://doi.org/10.1007/s12098-024-05098-x

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