Publication

Abstract : pThe main objective of any drug therapy is to achieve a desired concentration of the drug in blood or tissue which is therapeutically effective and non-toxic for an extended period of time. The aim of present work is to increase the biological half life and patient compliance of Indomethacin. For that purpose Indomethacin Microspheres were prepared using different polymers by Emulsion Solvent Evaporation Technique. The cumulative percentage drug release for all formulations of Indomethacin microspheres follow first order kinetics and they show increased dissolution rates. The result showed that the cumulative percentage release of Indomethacin from the formulations D:EC:HPMC(1:1:1), D:CE:EuRS100(1:1:1) D:EC:EuRL100(1:1:1), D:CA:EuRL100(1:1:1), D:CA:EuRS100(1:1:1) were 77.4%,78.2%,80.2%,88.74%and 83.5% respectively. Among these formulations D: CA: EuRL100 (1:1:1) shows similar percentage release as that of marketed drug (Indocide SR). Pharmacokinetic studies show that Cmax,tmax,AUC,t1/2 and MRT values of D:EC:EuRS100 and D:CA:EuRL100 formulations were increased compared to the marketed drugs The pharmacodynamic study revealed that anti inflammatory activity was well noticed in the microsphere formulation D:CA:EuRL100(1:1:1) than the marketed sample of Indomethacin and other microspheres formulation. So thereby these formulations have several advantages over the conventional form that the prolongation of drug action, improvement of bioavailability, patient compliance and reduction of gastro intestinal and centrally mediated side effects. In future the invitro-invivo correlation of the prepared formulation has to be done. Clinical evaluation is also under consideration./p