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Neonatal Candida auris infection: Management and prevention strategies – A single centre experience

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Journal Paediatrics Child Health,

Source : Journal Paediatrics Child Health, Volume56, Issue10, 2020

Url : http://dx.doi.org/10.1111/jpc.15019

Campus : Kochi

School : School of Medicine

Department : Microbiology

Year : 2020

Abstract : Aim Our aim was to identify the clinical features and outcome of multidrug resistant Candida auris (CA) infection in neonates. Methods This is a retrospective case cohort study of 17 neonates who developed sepsis caused by CA infection in a tertiary care neonatal intensive care unit over 3 years. The risk factors, clinical features, treatment and outcome were studied. Results The mean gestation was 32.4 ± 4.9 weeks with overall mortality of 41%. Clinical features were indistinguishable from other causes of sepsis. CA was sensitive to micafungin but resistant to fluconazole and had variable sensitivity to voriconazole and amphotericin. Survival improved to 83% when infants were treated with a combination of micafungin and amphotericin. Non-survivors were of lower birthweights and had other risk factors.

Cite this Research Publication : Jayasree Chandramati, Laleet Sadanandan, Anil Kumar, Sasidharan Ponthenkandath "Neonatal Candida auris infection: Management and prevention strategies – A single centre experience", Journal Paediatrics Child Health, 2020

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