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Multifunctional chitin nanogels for simultaneous drug delivery, bioimaging, and biosensing.

Publication Type : Journal Article

Thematic Areas : Nanosciences and Molecular Medicine

Publisher : ACS Publications

Source : ACS Appl Mater Interfaces, ACS Publications, Volume 3, Issue 9, Number 9, p.3654-65 (2011)

Url : http://pubs.acs.org/doi/abs/10.1021/am200844m

Keywords : Animals, Biosensing Techniques, Cadmium compounds, cattle, Cell Line, chitin, Chlorocebus aethiops, Drug Carriers, Humans, Mice, Microscopy, Fluorescence, Nanogels, Polyethylene glycols, polyethyleneimine, Quantum dots, Serum Albumin, Bovine, Spectroscopy, Fourier Transform Infrared, tellurium

Campus : Kochi

School : Center for Nanosciences

Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences

Department : Nanosciences and Molecular Medicine

Year : 2011

Abstract : In this work, we developed biodegradable chitin nanogels (CNGs) by controlled regeneration method. For multifunctionalization, we have conjugated CNGs with MPA-capped-CdTe-QDs (QD-CNGs) for the in vitro cellular localization studies. In addition, the Bovine Serum Albumin (BSA) was loaded on to QD-CNGs (BSA-QD-CNGs). The CNGs, QD-CNGs, and BSA-QD-CNGs were well-characterized by SEM and AFM, which shows that the nanogels are in the range of 100 nm. These were further characterized by FT-IR and Cyclic Voltametry. The cytocompatibility assay showed that the nanogels are nontoxic to L929, NIH-3T3, KB, MCF-7, PC3, and VERO cells. The cell uptake studies of the QD-CNGs were analyzed, which showed retention of these nanogels inside the cells (L929, PC3, and VERO). In addition, the protein loading efficiency of the nano gels has also been analyzed. Our preliminary studies reveal that these multifunctionalized nanogels could be useful for drug delivery with simultaneous imaging and biosensing.

Cite this Research Publication : S. Rejinold N, Chennazhi, K. Prasad, Tamura, H., Nair, S. V., and Rangasamy, J., “Multifunctional chitin nanogels for simultaneous drug delivery, bioimaging, and biosensing.”, ACS Appl Mater Interfaces, vol. 3, no. 9, pp. 3654-65, 2011.

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