Publication Type : Journal Article
Publisher : Cent Nerv Syst Agents Med Chem
Source : Cent Nerv Syst Agents Med Chem, Volume 16, Issue 2, p.120-36 (2016)
Url : https://pubmed.ncbi.nlm.nih.gov/26429556/
Keywords : Animals, Chalcones, Humans, Monoamine oxidase, Monoamine Oxidase Inhibitors, Structure-Activity Relationship
Campus : Kochi
School : School of Pharmacy
Center : Research & Projects
Department : Pharmaceutical Chemistry & Analysis
Verified : Yes
Year : 2016
Abstract : INTRODUCTION: Chalcones are one of the major classes of naturally occurring compounds and have a vast significance in medicinal chemistry, presenting with a wide scope of pharmacological actions. DISCUSSION: The present review focused our attention onto the monoamine oxidase inhibitory activity of natural and synthetic chalcones. The review also emphasises the structure-activity relationship studies and molecular recognition of chalcones towards MAO-A and B inhibition. CONCLUSION: Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A inhibitors.
Cite this Research Publication : Bijo Mathew, Haridas, A., Suresh, J., Mathew, G. E., Ucar, G., and Jayaprakash, V., “Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review.”, Cent Nerv Syst Agents Med Chem, vol. 16, no. 2, pp. 120-36, 2016.