Publication

Abstract : Background: Sepsis is a major cause of mortality among critically ill patients. The complex pathophysiology involves infection with systemic inflammatory response. Early detection of sepsis, helps not only is stratification of risk, but also for monitoring its progression and efficacy of therapeutic interventions. At present there are only few reliable prognostic tools to predict severity and mortality in sepsis. This study evaluates the usefulness of mean platelet value in prognosticating patient admitted with sepsis. Methods: We enrolled 200 patients prospectively, that have been admitted to our Medical ICU for sepsis over 2 years from 2018–2020. Changes in platelet indices, including mean platelet volume to platelet count ratio, were compared between survivors and non-survivors by using student’s t test. The prognostic value of mean platelet volume to platelet count ratio for 28-day mortality was ascertained by multivariate logistic regression. Results: Total 39 (19.5 %) patients expired within 28 days of ICU admission. MPV increased during the first 72 hours of hospital stay for both survivor and non survivors. Mean platelet volume to platelet count ratio was significantly higher in non survivors (P<0.001) as compared to survivors. In multivariate cox regression, mean platelet volume to platelet count ratio was an independent predictor of 28-day mortality, after adjusting for plausible confounders. Conclusions: Mean platelet volume to platelet count ratio is an independent risk factor for poor clinical outcomes. Hence monitoring mean platelet volume can prove as a simple tool to stratify the risk of mortality in septic patients.