Publication

Abstract : Papillary thyroid cancer (PTC) is the most common subtype of differentiated thyroid cancer and shows an increase in incidence globally. However, follicular thyroid carcinoma shows a decreasing trend in incidence but has aggressive biological behavior. The study focused on the long-term outcomes of follicular thyroid carcinoma and features predictive of adverse outcomes. After reviewing the histology, 22 patients with follicular thyroid carcinoma and these patients were treated during the study period. The median period of follow-up was 132 months. Disease-free survival (DFS) at the end of the study period was 59%, and adverse outcomes were recorded at 36%. Evident or obscure distant metastasis at the time of diagnosis was the strong predictor of adverse outcomes, which included disease-specific mortality. The most typical site of distant metastases was the lungs. The osseous metastases did not respond fully, even when iodine avidity was retained. Follicular thyroid carcinoma is an aggressive subtype of differentiated thyroid carcinoma (DTC) and requires aggressive management.