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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Journal of Food Science
Source : Journal of Food Science, Volume 75, Number 9, p.M546-M551 (2010)
Keywords : antibiosis, article, Bacteria (microorganisms), Bacterial Adhesion, bacterium adherence, Candida albicans, cell strain HT29, colon, development and aging, Enterococcus faecalis, Escherichia coli, food contamination, food control, Food Microbiology, growth, HT29 Cells, human, Humans, Hydrogen-Ion Concentration, isolation and purification, Lactobacillus, Lactobacillus fermentum, Lactobacillus sp., metabolism, methodology, microbiology, mucosa, Mucous Membrane, pathogenicity, pH, probiotic agent, Probiotics, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella paratyphi, Salmonella paratyphi A, Shigella sonnei, Staphylococcus aureus, Vibrio, Vibrio sp.
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2010
Abstract : Abstract: A number of Lactobacillus species are used as probiotic strains in order to benefit health. We have isolated L. fermentum from human colonic mucosal biopsy samples that possess antimicrobial activities against entroinvasive and foodborne pathogens such as Escherichia coli, Salmonella paratyphi A, Shigella sonnei, Staphylococcus aureus, Enterococcus faecalis, Proteus mirabilis, Pseudomonas aeruginosa, and Vibrio sp. In addition to lactic acid, L. fermentum secretes antimicrobial proteinacious compound(s) that was found to be active even at neutral pH (pH 7.0). The compound was sensitive to heat treatment and trypsin digestion. Lactobacillus fermentum inhibited the adhesion of enteropathogens to intestinal epithelial cells in vitro. Isolated cell surface associated proteins (SAPs) from L. fermentum were sufficient for the adhesion exclusions of enteropathogenic E. coli. Our results indicate that L. fermentum produces antimicrobial compounds and SAPs to inhibit the growth and adhesion of enteropathogens, respectively. © 2010 Institute of Food Technologists®.
Cite this Research Publication : P. Varma, Dinesh, K. R., Menon, K. K., and Dr. Raja Biswas, “Lactobacillus Fermentum Isolated from Human Colonic Mucosal Biopsy Inhibits the Growth and Adhesion of Enteric and Foodborne Pathogens”, Journal of Food Science, vol. 75, pp. M546-M551, 2010.