Publication Type : Journal Article
Thematic Areas : Medical Sciences
Publisher : Annals of Pediatric Cardiology
Source : Annals of Pediatric Cardiology, Volume 2, Number 1, p.74-78 (2009)
Keywords : bioassay, brain natriuretic peptide, carvedilol, Clinical trial, cyclosporin, digoxin, dizziness, drug bioavailability, drug clearance, drug contraindication, drug dose titration, drug efficacy, drug half life, drug information, drug mechanism, drug monitoring, drug safety, drug tolerability, dyspnea, e-mail, edema, first pass effect, gastrointestinal reflux, headache, health survey, heart atrium flutter, heart failure, heart left ventricle ejection fraction, human, hypotension, maintenance drug dose, medical expert, meta analysis, muscle fatigue, note, outcome assessment, pediatric advanced life support, pediatric cardiology, practice guideline, rifampicin, syncope, systematic review, thorax pain, treatment duration, treatment outcome, vomiting
Campus : Kochi
School : School of Medicine
Department : Paediatric Cardiology
Year : 2009
Abstract : Heart failure is a complex disorder characterized by widespread activation of various neurohormonal pathways resulting in increased circulating levels of catacholamines. In the short run, these circulating catacholamines may augment heart rate, blood pressure and myocardial contractility. However, chronic adrenergic stimulation leads to worsening of heart failure by inducing myocardial apoptosis and fibrosis.[1] Circulating catecholamines also cause peripheral vasoconstriction along with retention of salt and water, both of which are counterproductive. In addition, adrenergic stimulation may predispose to ventricular tachyarrhythmia and sudden cardiac death.
Cite this Research Publication : B. Vaidyanathan, “Is there a role for carvedilol in the management of pediatric heart failure A meta analysis and e-mail survey of expert opinion”, Annals of Pediatric Cardiology, vol. 2, pp. 74-78, 2009.