Publication

Abstract : The treatment of cancer is mainly through chemotherapy, radiational therapy and surgery. However there are many limitations for the conventional use of cytotoxic drugs which may result in lack of selectivity in the body and the intrinsic or acquired multidrug resistance of cancer cells. Hence to end this nano dendritic polymer is used as drug carriers due to their diverse chemistry and safety characteristics in the body. Dendrimers are hyper branched distinctive class of macromolecules having highly branched; three-dimensional architectures with low polydispersity and high functionality .Compared to classical polymers, dendrimers have a sharp degree of molecular uniformity, narrow molecular weight distribution, unambiguous size and shape characteristics, and a high- functionalized terminal surface. Due to their high flexibility, nano-size, and well defined structure dendrimers are used as promising scaffolds and have diverse applications in the field of biomedicine. Different types of interactions like electrostatic, hydrophobic and hydrogen bond interactions take place during entrapment of drugs within the dendritic polymer and the covalent and electrostatic interaction between a drug and the surface of a polymer have been analyzed. Molecular simulations have been used in this work to study the various properties of Polyamidoamine (PAMAM) dendrimers both in equilibrium as well as in the transient or steady-state flows. Hence an insight into these analyses will help us to study how the molecular properties help in anticancer drug delivery.