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Injectable polyethylene glycol terminated poly (propylene fumarate) / acrylamide biodegradable materials for cardiac applications

Publication Type : Journal Article

Publisher : Hacettepe J Biol Chem

Source : Hacettepe J Biol Chem 36(4) 283-290

Url : https://dergipark.org.tr/en/download/article-file/1727549

Keywords : Injectable and biodegradable hydrogel, Polyethylene glycol terminated pol(propylene fumarate)/acrylamide, Fast

Campus : Amritapuri

School : School of Biotechnology

Department : biotechnology

Year : 2008

Abstract : Injectable and biodegradable hydrogel material based on polyethylene glycol terminated poly(propylene fumarate)(PEG-PPF-PEG)/ acrylamide have been developed and evaluated for cardiac applications. The present PEG-PPF-PEG resin undergoes fast setting with acrylamide with low exothermic temperature and mechanical properties equivalent to that of cardiac tissue. The chemically cross linked hydrogels undergo swelling in Ringer’s solution prior to degradation. The present material are non cytotoxic to L-929 fibroblast and compatible with the cardiac fibroblast cells. Adhesion and proliferation of cardiac fibroblast cells has been appreciably good which is due to surface reorganisation and generation of synergistic hydrophilic-hydrophobic surface

Cite this Research Publication : Injectable polyethylene glycol terminated poly (propylene fumarate) / acrylamide biodegradable materials for cardiac applications (2008) Kallukalam BC, Jayabalan M and Sankar V Hacettepe J Biol Chem 36(4) 283-290

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