Publication Type : Journal
Publisher : MDPI
Source : Viruses
Url : https://www.mdpi.com/1999-4915/14/12/2656
Campus : Kochi
School : Center for Nanosciences, School of Nanosciences
Center : Nanosciences
Year : 2022
Abstract : Dengue fever is a mosquito-borne viral disease that has become a serious health issue across the globe. It is caused by a virus of the Flaviviridae family, and it comprises five different serotypes (DENV-1 to DENV-5). As there is no specific medicine or effective vaccine for controlling dengue fever, there is an urgent need to develop potential inhibitors against it. Traditionally, various natural products have been used to manage dengue fever and its co-morbid conditions. A detailed analysis of these plants revealed the presence of various chromene derivatives as the major phytochemicals. Inspired by these observations, authors have critically analyzed the anti-dengue virus potential of various 4H chromene derivatives. Further, in silico, in vitro, and in vivo reports of these scaffolds against the dengue virus are detailed in the present manuscript. These analogues exerted their activity by interfering with various stages of viral entry, assembly, and replications. Moreover, these analogues mainly target envelope protein, NS2B-NS3 protease, and NS5 RNA-dependent RNA polymerase, etc. Overall, chromene-containing analogues exerted a potent activity against the dengue virus and the present review will be helpful for the further exploration of these scaffolds for the development of novel antiviral drug candidates.
Cite this Research Publication : Dharmapalan, B.T., Biswas, R., Sankaran, S., Venkidasamy, B., Thiruvengadam, M., George, G., Rebezov, M., Zengin, G., Gallo M., Montesano, D., Naviglio, D., Shariati, M.A. Inhibitory Potential of Chromene Derivatives on Structural and Non-Structural Proteins of Dengue Virus (2022) Viruses, 14, 2656.