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In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin- 2-amines

Publication Type : Journal Article

Source : BioMed Research International, 2014

Url : https://www.hindawi.com/journals/bmri/2014/971569/

Campus : Bengaluru

School : School of Artificial Intelligence

Verified : No

Year : 2014

Abstract : An in vitro antidiabetic activity on α-amylase and α–glucosidase activity of novel 10-chloro-4-(2-chlorophenyl)-12-phenyl-5,6-dihydropyrimido[4,5-a]acridin-2-amines (3a–3f) were evaluated. Structures of the synthesized molecules were studied by FT-IR, 1H NMR, 13C NMR, EI-MS, and single crystal X-ray structural analysis data. An in silico molecular docking was performed on synthesized molecules (3a–3f). Overall studies indicate that compound 3e is a promising compound leading to the development of selective inhibition of α-amylase and α-glucosidase.

Cite this Research Publication : Bharathi A, Roopan SM, Vasavi CS, Munusami P, Gayathri GA, Gayathri M, et al. "In Silico Molecular Docking and In Vitro Antidiabetic Studies of Dihydropyrimido[4,5-a]acridin- 2-amines", BioMed Research International, 2014; 2014: e971569, Hindawi, Impact Factor: 3.25

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