Publication Type : Journal Article
Publisher : Int. J. Pharm. Sci. Rev.
Source : Int. J. Pharm. Sci. Rev. , vol. 40, no. 2, pp. 92-102 , 2016
Campus : Kochi
School : School of Pharmacy
Department : Pharmaceutical Chemistry & Analysis
Verified : Yes
Year : 2016
Abstract : Indole compounds are well known for their wide variety of pharmacological activities. It is the combination of benzene with pyrrolering. Compounds having indole group are biologically important. They are used as antimicrobial, antiviral, antituberular, antiinflammatory,anticancer, ant-diabetic and anticonvulsant agents. Because of the wide variety of biological application, severalsubstituted indole derivatives are studied for their molecular structure, molecular docking and bioavailability. The purpose of thestudy is to carry out the docking studies of indole derivatives containing electrophilic substitution and nucleophilic substitution withthe anticancer target casp9. Fifty compounds were designed and by using Argus lab version 4.0.1. Their docking score was calculatedand compared with the standard drug casodex. The drug likeness of compounds was performed using Lipinski rule of five. Resultshowed that 1,1’-(1H-indole-5,6-diyl)diethanone and 5-(trichloromethyl)-1H-indole and the phytoconstituent curcumin showedbetter docking score than that of the standard drug casodex. It is concluded that certain indole derivatives show greater affinity withcasp9 protein. These compounds may be helpful in studying anticancer targets for casp9 protein.
Cite this Research Publication : A. S. Sekhar, .T.S, S., Baskar, V., and Asha Asokan Manakadan, “In Silico Approach of Apoptosis Inducing Ability of Different Indole Derivatives by Interaction with CASPASE9”, Int. J. Pharm. Sci. Rev. , vol. 40, no. 2, pp. 92-102 , 2016