Publication

Abstract : A novel spheronisation technique is reported here for forming spherules from granules using FDA approved excipients and common pharmaceutical unit operations. The aspirin is used as a model drug to check stability during the process. For that, spherules are prepared by "bed coating during sliding" (BCDS) of granules. Spherules with two size range (sieve no 22 and 44) are compared. These spherules are further coated with polymers to show the versatility of the process. They are characterised by microscopical evaluation, flow property determination, drug content evaluation and in vitro drug release studies. Microscopical evaluation reveal that number of edges (90° and 45°) are less for spherules compared to granules. Angle of Repose sand packing parameters appeared excellent. Different polymer coating gives different release profile as per the properties of the polymer. However, the drug content is lower for 44 as compared to 22 while drug release profile appears similar. This is a robust and versatile platform delivery system for developing advanced drug delivery systems (ADDS). However, the stability of aspirin is affected by the wet process may be because aspirin is a hydrolytically labile drug.