Publication

Abstract : Objective: The objective of the present study was to formulate a controlled release floating tablet of Olmesartan Medoxomil. Methods: Floating tablets of Olmesartan Medoxomil were prepared by direct compression method using both natural (sodium alginate and carrageenan) and semi synthetic polymers (HPMC K4M, HPMC K100LV and HPMC E50LV).Sodium bicarbonate and calcium carbonate were used as gas generating agents. The floating tablets were evaluated for their hardness, friability, drug content, invitro buoyancy, invitro dissolution, swelling and stability studies. Effect of different polymers and gas forming agents on the drug release from the tablet was studied. Result: The optimized formulation F3 with HPMC K4M and sodium bicarbonate showed good physical properties and short floating lag time (55.8 sec). Conclusion: The drug release from the tablet was sustained and non-fickian transport of drug from the tablet was confirmed.