Publication Type : Journal Article
Publisher : Wiley
Source : Chemistry Select, 2017
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2017
Abstract : Stereoselective total synthesis of Ligraminol E has been achieved in 8 steps in 23.9 % overall yield by employing an imidazolidinone based chiral auxiliary. The key steps involved in the synthesis are the asymmetric glycolate alkylation of (R)‐3‐(2‐(benzyloxy)acetyl)‐4‐isopropyl‐1‐((S)‐1‐phenylethyl)imidazo‐lidin‐2‐one with substituted benzyl bromide and the Mitsonobu reaction of a secondary alcohol and phenolic group.
Cite this Research Publication : Mukesh Gangar, Sandeep Goyal, Vankodoth Hathiram, Wasnik Ashik Ramdas, Vajja Krishna Rao and Vipin A. Nair* "First stereoselective total synthesis of ligraminol E", Chemistry Select 2017, 2, 257-259