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Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Chem Biol Drug Des,
Source : Chem Biol Drug Des, Volume 90, Issue 4, p.629-636 (2017)
Url : https://www.ncbi.nlm.nih.gov/pubmed/28303669
Keywords : Antineoplastic Agents, Computer-Aided Design, Databases, Pharmaceutical, drug design, ErbB Receptors, Erlotinib Hydrochloride, gefitinib, Humans, Hydroxamic Acids, Molecular Docking Simulation, Mutation, Protein Kinase Inhibitors, Quantitative Structure-Activity Relationship, Quinazolines, Small Molecule Libraries
Campus : Amritapuri
School : Center for Nanosciences, School of Biotechnology
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2017
Abstract : Present work elucidates identification of next generation inhibitors for clinically relevant mutations of epidermal growth factor receptor (EGFR) using structure-based bioactive pharmacophore modeling followed by virtual screening (VS) techniques. Three-dimensional (3D) pharmacophore models of EGFR and its different mutants were generated. This includes seven 3D pharmacophoric points with three different chemical features (descriptors), that is, one hydrogen bond donor, three hydrogen bond acceptors and three aromatic rings. Pharmacophore models were validated using decoy dataset, Receiver operating characteristic plot, and external dataset compounds. The robust, bioactive 3D e-pharmacophore models were then used for VS of four different small compound databases: FDA approved, investigational, anticancer, and bioactive compounds collections of Selleck Chemicals. CUDC101 a multitargeted kinase inhibitor showed highest binding free energy and 3D pharmacophore fit value than the well known EGFR inhibitors, Gefitinib and Erlotinib. Further, we obtained ML167 as the second best hit on VS from bioactive database showing high binding energy and pharmacophore fit value with respect to EGFR receptor and its mutants. Optimistically, presented drug discovery based on the computational study serves as a foundation in identifying and designing of more potent EGFR next-generation kinase inhibitors and warrants further experimental studies to fight against lung cancer.
Cite this Research Publication : P. S. Panicker, Melge, A. R., Biswas, L., Keechilat, P., and Mohan, C. G., “Epidermal growth factor receptor (EGFR) structure-based bioactive pharmacophore models for identifying next-generation inhibitors against clinically relevant EGFR mutations.”, Chem Biol Drug Des, vol. 90, no. 4, pp. 629-636, 2017.