Publication Type : Journal Article
Thematic Areas : Nanosciences and Molecular Medicine
Publisher : Nanoscale
Source : Nanoscale, Volume 3, Number 6, p.2461-2464 (2011)
Keywords : animal, Animals, article, Cell Survival, Cercopithecus, Cercopithecus aethiops, chemical phenomena, chemistry, Confocal, confocal microscopy, drug effect, flow cytometry, Graphite, Hydrophobic and Hydrophilic Interactions, Materials Testing, microscopy, nanomaterial, Nanostructures, oxidative stress, toxicity testing, Toxicity Tests, Vero cell, Vero cells
Campus : Kochi
School : Center for Nanosciences
Center : Amrita Center for Nanosciences and Molecular Medicine Move, Nanosciences
Department : Nanosciences and Molecular Medicine
Year : 2011
Abstract : We report the effect of carboxyl functionalization of graphene in pacifying its strong hydrophobic interaction with cells and associated toxic effects. Pristine graphene was found to accumulate on the cell membrane causing high oxidative stress leading to apoptosis, whereas carboxyl functionalized hydrophilic graphene was internalized by the cells without causing any toxicity.
Cite this Research Publication : Abhilash Sasidharan, Panchakarla, L. S., Chandran, P., Dr. Deepthy Menon, Nair, S., Rao, C. N., and Koyakutty, M., “Differential Nano-bio Interactions and Toxicity Effects of Pristine Versus Functionalized Graphene”, Nanoscale, vol. 3, pp. 2461-2464, 2011.