Publication Type : Journal Article
Thematic Areas : Advanced Materials and Green Technologies
Publisher : Investigative Magnetic Resonance Imaging
Source : Investigative Magnetic Resonance Imaging, Volume 23, Issue 1, p.17–25 (2019)
Url : https://synapse.koreamed.org/DOIx.php?id=10.13104/imri.2019.23.1.17
Keywords : MR contrast agent, pH-mapping, T1-W MRI
Campus : Coimbatore
School : School of Engineering
Center : Center for Excellence in Advanced Materials and Green Technologies, Center for Industrial Research and Innovation (ACIRI)
Department : Civil
Year : 2019
Abstract : We discuss recent advances in Gd-based T1-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as 3 mm3. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.