Publication

Abstract : In the synthetic organic chemistry, construction of carbon-carbon bond is one of the most fundamental reactions. Therefore, new strategies for development of carbon-carbon bonds have been continuous to be the most challenging and attractive endeavour to synthetic organic chemists. Several C-C bond forming reactions such as Aldol reaction,1 Suzuki coupling,2 Grignard reaction,3 Baylis-Hillman reaction,4,5 Heck reaction, 6 Diels-alder reaction7 and Wittig reaction8 etc. have been well established. Applications of these reactions in the synthesis of various molecular frameworks including carbocycles, heterocycles, medicinally important compounds and natural products are efficiently performed. The Stetter reaction9-21 is yet another important carbon-carbon bond forming reaction which is growing rapidly in recent years. Large number of articles published in literature is the clear indicator of the importance of this reaction. It possesses atom economy, stereo and regio-selectivity which are the most essential requirements for the development of an efficient synthetic reaction. It enables a new catalytic pathway for the synthesis of various 1, 4-bifunctional molecules such as diketones, ketoesters and ketonitriles etc. can be catalyzed by a broad range of thiazolium and triazolium salts which make this reaction more attractive in the synthetic organic chemistry. Even after the 35 years of its birth, there is no complete review on this reaction though a number of publications found in recent years. Therefore, We felt urgency of the review on the Stetter reaction covering the literature of about three decade will be useful for growth this reaction in organic chemistry. Hence, we have taken the opportunity of writing this review, which covering all the literature of last 35 years to recent ones and also describes the way how the reaction was grown with respect of asymmetric and intramolecular versions. Another important purpose of writing this review is to provide an exposer to the Stetter reaction which indeed may help for its development, and also this may motivate organic chemists to think of the new applications of the reaction. Pioneering work done by Ciganek, Enders, Glorius, Trost and Rovis are found to be very fruitful for the development of Stetter reaction.