Publication

Abstract : Wound healing is a tightly regulated process, and the presence of bacteria hinders the process, resulting in infectious wounds. Chronic wounds result in persistent inflammation, which leads to oxidative stress, infection-prone, and accumulation or formation of biofilm; the best example is a diabetic foot ulcer. Tremendous research addresses this issue in developing effective antimicrobial medication delivery systems. However, several antimicrobial therapies are on the market, but tissue repair and regeneration are in high demand. Various biomedical and biomaterial research has been employed for the past two decades to help with this. Porous scaffolds and hydrogels as possible drug-delivery biomaterials are the best candidates on the list. Hence, effective delivery of various antimicrobial agents to the wound site is obligatory for impeding microbial growth and expediting tissue rejuvenation by aiding extracellular matrix (ECM) analogs, vascularization, cell adhesion, and re-epithelialization for accomplishing tissue repair and regeneration. This review primarily focuses on the research investigations about treating chronic and infectious wounds using polymeric scaffolds and hydrogels on the animal model, preclinical studies, and their translation.