Publication

Abstract : In Sikkim, nearly 35% of state population above the age of 21 years are chronic alcoholics. Forty five cases of alcoholics were studied to detect liver injury. Bilirubin, total protein, albumin, transaminases (AST and ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), superoxide dismutase (SOD) and Glutathione peroxidase (GPx) of serum were estimated in these subjects. In moderate alcohol consumption, GGT level, GPx and SOD activities are increased moderately. Mild increase in bilirubin, hypoalbuminemia and moderate increased in ALP were observed in chronic alcoholics. In chronic alcoholics GGT level remained very high, while GPx and SOD activity increased significantly.