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Publication Type : Journal Article
Publisher : The National Medical Journal of India
Source : The National Medical Journal of India. 2020 May 1;33(3):149.
Url : https://www.nmji.in/content/141/2020/33/3/Images/NatlMedJIndia_2020_33_3_149_314007.pdf
Campus : Faridabad
Year : 2020
Abstract : Methaemoglobinaemia in G6PD deficiency can be managed by oxidizing agents such as methylene blue and red cell exchange (RCE). We describe a G6PD-deficient patient who presented with oxidative stress with methaemoglobinaemia and was successfully managed with automated-RCE. At presentation, the patient had anaemia, was restless, was tired and had dyspnoea. Co-oximetry showed methaemoglobinaemia of 10.1 U/g. Further testing revealed the patient had insufficient quantities of G6PD enzyme activity (0.1 U/g Hb). In view of methaemoglobinaemia, sever G6PD deficiency and signs of haemolysis, therapeutic RCE was planned. The patient underwent two automated-RCE procedures on consecutive days, bringing down his methaemoglobin levels from 12.5 to 0.1 U/g. In each procedure, 1.5 volumes of RCE at 100% balance rate was performed using 5 units of red blood cells. The patient responded well to RCE and other supportive treatment and was off medication and doing well at day 100 of follow-up.
Cite this Research Publication : Tiwari A, Aggarwal G, Gupta V, Arora D, Pabbi S, Rawat G. Automated-red cell exchange for methemoglobinemia in a G6PD-deficient patient. The National Medical Journal of India. 2020 May 1;33(3):149.