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Asian journal of pharmaceutical and clinical research: A case report on role of N-acetylcysteine in non-acetaminophen-related acute liver injury

Publication Type : Journal Article

Thematic Areas : Medical Sciences

Publisher : Asian Journal of Pharmaceutical and Clinical Research, Innovare Academics Sciences Pvt. Ltd.

Source : Asian Journal of Pharmaceutical and Clinical Research, Innovare Academics Sciences Pvt. Ltd, Volume 9, Number 6, p.7-8 (2016)

Url : https://www.scopus.com/inward/record.uri?eid=2-s2.0-84994804669&partnerID=40&md5=610d5145a0f0b43cbc6a4f7994d3824f

Campus : Kochi

School : School of Medicine, School of Pharmacy

Department : Emergency Medicine, Pharmacy Practice

Year : 2016

Abstract : Acute liver failure (ALF) is a clinical entity associated with a high mortality rate, and the majority of these patients may require liver transplantation. N-Acetylcysteine (NAC), an antioxidant agent that replenishes mitochondrial and cytosolic glutathione stores, is an antidote for acetaminophen poisoning. However, their role in non-acetaminophen-related ALF is still not proven. Here, we discuss a 67-year-old male patient diagnosed with hepatitis with an acute liver injury who was admitted to Emergency Medicine. He was treated with NAC infusion for an average of 48 hrs, and later, it was found that his liver function tests improved. In this study, we could find that NAC plays a major role in improving the liver function test of patients with non-acetaminophen-related ALF.

Cite this Research Publication : A. Thampi, Joy, J., Kumar, G., Sreekrishnan, T. P., and Ajith, V., “Asian journal of pharmaceutical and clinical research: A case report on role of N-acetylcysteine in non-acetaminophen-related acute liver injury”, Asian Journal of Pharmaceutical and Clinical Research, vol. 9, pp. 7-8, 2016.

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