Publication Type : Journal Article
Publisher : Wiley
Source : Chemistry Select, 2017
Campus : Amritapuri
School : School of Biotechnology
Verified : No
Year : 2017
Abstract : Asymmetric Mannich‐type reaction employing 5‐isopropyl‐3‐phenyl‐2‐thioxoimidazolidin‐4‐one as a chiral auxiliary with various aldimines to obtain enantiomerically enriched β‐amino carbonyl functionalities with good yields and high trans‐diastereoselectivities has been described. In order to establish the stereochemical outcome of the reaction, the Mannich‐adduct was hydrolysed using LiOH/H2O2 and subsequently cyclized with thionyl chloride to afford the corresponding β‐lactam in good yield and high stereoselectivity.
Cite this Research Publication : Sandeep Goyal, Gaurang V. Garasiya, Mukesh Gangar, Nikitha Gaddam, Maulik N. Mungalpara, Sagar Ravso Mudshinge and Vipin A. Nair* "An auxiliary mediated alkylation approach towards the synthesis of β-aminocarbonyl derivatives", Chemistry Select 2017, 2, 745-747