Publication

Abstract : MicroRNA is the non-coding RNA in the gene sequences, is the major factor of invoking the oncogenes. Late identification of lung cancer leads to deaths. Multiple studies on miRNAs have made a break through discoveries including their direct and indirect involvements in causing lung cancer. Several miRNAs like miR-21a, miR-196 and miR-69 are identified as bio marking elements of non-small cellular lung cancer few like miR138 and let-7 are considered as anti-cancer agents. This work studies the changes happening to miR-138 in interaction with NSCLC drugs. miRNA use to interact with multiple natural factors, utilizing this property of miRNA we examined the possibility of studying different drug effects on miR-138. Target Scan, Mol View, and free energy calculation algorithm were used for creating an interactive environment for the simulation. From the results, we conclude that miRNAs are reactive to cancer drugs. This could be used for further development of cancer prevention drugs which targets miRNAs rather than oncogenes.