Publication Type : Journal Article
Thematic Areas : Advanced Materials and Green Technologies
Publisher : Journal of the American Chemical Society
Source : Journal of the American Chemical Society, Volume 136, Number 39, p.13888-13894 (2014)
Url : http://dx.doi.org/10.1021/ja5077684
Campus : Coimbatore
School : School of Engineering
Center : Center for Excellence in Advanced Materials and Green Technologies
Department : Civil
Year : 2014
Abstract : pMetastatic cancers have historically been difficult to treat. However, metastatic tumors have been found to have high levels of reactive oxygen species such as hydrogen peroxide (H2O2), supporting the hypothesis that a prodrug could be activated by intracellular H2O2 and lead to a potential antimetastatic therapy. In this study, prodrug 7 was designed to be activated by H2O2-mediated boronate oxidation, resulting in activation of the fluorophore for detection and release of the therapeutic agent, SN-38. Drug release from prodrug 7 was investigated by monitoring fluorescence after addition of H2O2 to the cancer cells. Prodrug 7 activated by H2O2, selectively inhibited tumor cell growth. Furthermore, intratracheally administered prodrug 7 showed effective antitumor activity in a mouse model of metastatic lung disease. Thus, this H2O2-responsive prodrug has therapeutic potential as a novel treatment for metastatic cancer via cellular imaging with fluorescence as well as selective release of the anticancer drug, SN-38./p
Cite this Research Publication : E. - J. Kim, Bhuniya, S., Lee, H., Kim, H. Min, Cheong, C., Maiti, S., Hong, K. Soo, and Kim, J. Seung, “An Activatable Prodrug for the Treatment of Metastatic Tumors”, Journal of the American Chemical Society, vol. 136, pp. 13888-13894, 2014.